Lens produces hours of scientific work in seconds

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Dr Brad Amos
Dr Brad Amos. Photo courtesy Medical Research Council




13 February 2012

A new form of microscope which can produce results in seconds rather than hours- dramatically speeding up the process of drug development- is being developed at Strathclyde.

Scientists are creating a lens which will be capable of showing three-dimensional images within cells and tissues at the same time as showing the whole organism, something which is currently not possible with any single imaging device.

The innovative Mesolens – the only device of its kind in the world - will be able to capture detail in organisms which are too big to be examined satisfactorily by existing microscopes and will offer a deeper insight into areas such as cancerous tissues and the cortex of the brain.

Dr Brad Amos, a Visiting Scientist at the Strathclyde Institute of Pharmacy and Biomedical Sciences, discussed the device at the prestigious Leewenhoek Lecture, which is given every three years and recognises excellence in the life sciences, at the Royal Society in London.



Dr Amos, who is also Emeritus Research Group Leader in the Medical Research Council (MRC) Laboratory of Molecular Biology and a Fellow of the Royal Society, said: “The global health challenges of the 21st century demand new and powerful treatments but the process of drug discovery and delivery is often time-consuming and costly.

"The information provided by microscopes is vital to this process but can take hours at a time to emerge. The confocal lens can be trained simultaneously on or inside an individual cell and the full organism, with strong resolution and will have the capacity to deliver 3D images which go far beyond the limitations of 2D representations.

“This level of detail can open up vast possibilities for discoveries which can contribute to the fight against disease worldwide.”



human flea
An image, captured by the Mesolens, of a human flea. Image courtesy Medical Research Council.

Dr Gail McConnell, a Reader at the Strathclyde Institute of Pharmacy and Biomedical Sciences, is a partner in the research. She said: “Our research fits with Strathclyde’s ethos of technical innovation with universal impact. We already have the two-dimensional technology for the lens in place, but a third dimension will allow us to take the revolutionary step of presenting images with a range and versatility which no single imaging platform can currently offer.”

Dr Amos’ secondment to the University of Strathclyde is being funded through a Knowledge Transfer Account from the Engineering and Physical Sciences Research Council. The research has also received funding from the MRC. Dr Amos and Dr McConnell are working closely with the University’s Research & Knowledge Exchange Services to commercialise the output of this research.

The research forms part of Advanced Science & Technology- one of the principal themes of the University’s Technology and Innovation Centre (TIC), a world-leading research and technology centre transforming the way universities, business and industry collaborate.

Leading academics are working with industry and the health sector to find technologies for earlier, more accurate disease detection and better treatments, as well as life-long disease prevention.

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